Endorsed Kamala Harris and donated $214K+ to Democratic candidates before 2024 election, including to Biden, Clinton, and the DNC. Wrote a now-deleted Facebook post calling Trump "a serious and legitimate threat to the rule of law." In February 2026 a leaked internal memo showed Amodei told ~2,000 Anthropic staff the Trump administration was hostile to the company because it had not given "dictator-style praise" to Trump and refused to donate to him. He publicly apologized after the memo leaked.